The Interior of the Mercedes-Benz E-Class are as follow:
| Variants | 2019 Mercedes-Benz E-Class E 200 SportStyle Avantgarde | 2019 Mercedes-Benz E-Class E 300 Exclusive Line | 2019 Mercedes-Benz E-Class E 350 AMG Line |
| Sunroof | - | Panoramic | Panoramic |
| Sunshade | Powered rear sun shade, manual rear door window sun shades | Powered rear sun shade, manual rear door window sun shades | Powered rear sun shade, manual rear door window sun shades |
| Seat Features(Front-Driver) | Power Adjustable Seats with Memory Function | Power Adjustable Seats with Memory Function | Power Adjustable Seats with Memory Function |
| Seat Features(Passenger) | |||
| Seat Features(Rear) | 40:20:40 Split-folding | 40:20:40 Split-folding | 40:20:40 Split-folding |
| Cupholders | 2 Front, 2 Rear | 2 Front, 2 Rear | 2 Front, 2 Rear |
| Front Air-con | Dual-zone Automatic Climate Control System | Dual-zone Automatic Climate Control System | Dual-zone Automatic Climate Control System |
| Rear Air-con | Y | Y | Y |
| Paddle Shift | Y | Y | Y |
| Multi-function Steering Wheel | Y | Y | Y |
| Steering Tilt | Y | Y | Y |
| Steering Telescopic | Y | Y | Y |
| Steering Adjustment Electric | Y | Y | Y |
| Engine Start | Keyless Push Button | Keyless Push Button | Keyless Push Button |
| Head-up Display | - | Y | Y |
