The Safety of the Mercedes-Benz E-Class are as follow:
| Variants | 2019 Mercedes-Benz E-Class E 200 SportStyle Avantgarde | 2019 Mercedes-Benz E-Class E 300 Exclusive Line | 2019 Mercedes-Benz E-Class E 350 AMG Line |
| Euro NCAP Rating | 10 | 10 | 10 |
| ASEAN NCAP Rating | 0 | None | 0 |
| Airbags | 7 | 7 | 7 |
| Driver/Front Passenger Seat Airbags | Y/Y | Y/Y | Y/Y |
| Front/Rear Side Airbags | - | - | - |
| Front/Rear Curtain Airbags | Y/Y | Y/Y | Y/Y |
| Knee Airbags | Driver Knee | Driver Knee | Driver Knee |
| Rear Airbags | |||
| Airbag Disable Function | |||
| Seatbelt Reminder | All Seats | All Seats | All Seats |
| Autonomous Emergency Braking | Y | Y | Y |
| Lane-keeping Alert | N | N | Y |
| Blind Spot Info System | Y | Y | Y |
| Collision Warning | Y | Y | Y |
| ABS/EBD | Y | Y | Y |
| Electronic Stability Control(ESC) | Y | Y | Y |
| Child Safety Lock | Manual for rear doors | Manual for rear doors | Manual for rear doors |
| ISOFIX | Y | Y | Y |
| Security Alarm | Y | Y | Y |
| Immobilizer | Y | Y | Y |
